A Randomised Controlled Trial to Prevent Eczema, Food Allergy and Sensitisation Using a Skin Barrier Improvement Strategy

Grant number: 1130010 | Funding period: 2017 - 2022

Completed

Abstract

In this world first study, we will test if building the infant skin barrier by using daily regular skin care treatment can reduce the incidence of eczema. If successful, this trial will alter infant skin care practices and reduce the burden of allergic diseases in our community. Furthermore, as infants with eczema having a poor skin barrier, which possibly increases their risk of developing sensitisation, we will test if this intervention reduces the risk of food allergy.

Related publications (2)

Early-life protein-bound skin ceramides help predict the development of atopic dermatitis

CL Chang, E Berdyshev, E Milanzi, CJ Lodge, DJ Lopez, I Bronova, JJ Koplin, RL Peters, MLK Tang, SC Dharmage, MJ Abramson, J Hui, G Varigos, KP Perrett, A Sasi, JL Perret, JC Su, PD Robinson, DYM Leung, AJ Lowe

2025-03-01

Background: Skin lipids are crucial components of the skin barrier. Individuals with atopic dermatitis (AD or eczema) have a diffe..

PEBBLES study protocol: A randomised controlled trial to prevent atopic dermatitis, food allergy and sensitisation in infants with a family history of allergic disease using a skin barrier improvement strategy

A Lowe, J Su, M Tang, CJ Lodge, M Matheson, KJ Allen, G Varigos, A Sasi, N Cranswick, S Hamilton, CF Robertson, J Hui, M Abramson, S O'Brien, S Dharmage

2019-03-01

Introduction The skin is an important barrier against environmental allergens, but infants have relatively impaired skin barrier f..

University of Melbourne Researchers

Adrian Lowe

Mimi Tang

Shyamali Dharmage